Stiff person syndrome

Serum anti-GAD glutamic acid decarboxylase 65 antibody serum amphiphysin antibody several other serum autoantibodies hemoglobin A1c and vitamin levels lumbar puncture MRI of the brain and spine neurophysiological studies. Stiff-person syndrome SPS is a rare and disabling central nervous system disorder with no satisfactory treatment.

Stiff Person Syndrome Insights Into A Complex Autoimmune Disorder Journal Of Neurology Neurosurgery Psychiatry

SPS is strongly correlated with autoimmune diseases and it is usual to find high titers of antibodies against acid decarboxylase GAD65.

. Certain cancers including breast lung kidney thyroid colon and Hodgkins lymphoma. SPS is labeled as a rare disease. Myoclonus is a general term used to describe the sudden involuntary jerking of a muscle or group of muscles caused by muscle contractions positive myoclonus or.

Symptoms include muscle spasms hyper-rigidity debilitating pain and chronic anxiety. Symptoms may include extreme muscle stiffness rigidity and painful spasms in the trunk and limbs severely impairing mobility. Jerking stiff-person syndrome is characterized by muscles stiffness and spasms usually affecting the legs.

The stiffness primarily affects the truncal muscles and is superimposed by spasms resulting in postural deformities. Stiff person syndrome SPS is a neurological disease with autoimmune features. SPS is characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli such as noise touch and emotional distress which can set off muscle spasms.

Stiff Person Syndrome SPS is an autoimmune and neurological disorder that can make the muscles in the torso and limbs alternate between rigidity and spasms. Stiff person syndrome is characterized by muscle rigidity and spasms heightened sensitivity to stimuli such as sound and lights and emotional distress that can cause muscle spasms according to. SPS occurs in about one in a.

Muscle rigidity sporadic muscle spasms and chronic muscle pain characterize SPS. Stiff person syndrome SPS is a rare progressive syndrome that affects the nervous system specifically the brain and spinal cord. Stiff person syndrome is more likely seen in people with certain types of diseases including.

Stiff-person syndrome also known as stiff-man syndrome is a rare neurologic disorder of unclear cause characterized by progressive rigidity and stiffness. Spasms can generate enough force to fracture bone. Stiff-person syndrome SPS is a rare neurological disorder with features of an autoimmune disease.

Autoimmune disorders including diabetes thyroiditis vitiligo and pernicious anemia. Affected individuals also develop involvement of the brainstem which can cause myoclonus. Tests for diagnosing stiff person syndrome may include the following.

But more people are affected than reported due to misdiagnoses. Chronic pain impaired mobility and lumbar hyperlordosis are common symptoms. Muscle spasms can be so violent they can dislocate joints and even break bones.

The cause of this extremely rare disease is still unknown.

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